Clinical effect analysis of acetylcysteine granules combined with azithromycin in the treatment of mycoplasma pneumoniae pneumonia in children
Objective To study the effect of acetylcysteine granules combined with azithromycin in the treatment of mycoplasma pneumoniae pneumonia in children. Methods 60 children with mycoplasma pneumoniae pneumonia were divided into a control group and a study group by different numbers,with 30 cases in each group. The control group was given oral azithromycin for suspension,and the study group was given azithromycin+acetylcysteine granules combined treatment. The clinical indicators,inflammatory factors,lung function indicators and treatment effect were compared between the two groups. Results In the study group,the duration of hospitalization was (8.12±2.15) d,the disappearance time of cough was (12.28±2.25) d,the time of fever reduction was (3.62±1.23) d,the disappearance time of shortness of breath was (3.08±1.15) d,and the disappearance of sputum sound was (12.26±1.34) d,which were shorter than (9.42±2.12),(13.76±2.33),(4.53±1.05),(4.19±1.75),and (13.48±1.26) d in the control group,and the difference was significant (P<0.05). In the study group,the tumor necrosis factor-α (TNF-α) was (3.21±0.66) ng/ml,the procalcitonin (PCT) was (0.45±0.02) ng/ml,and the interleukin-6 (IL-6) was (10.11±2.14) ng/L,which were lower than (4.56±0.74) ng/ml,(0.53±0.03) ng/ml and (13.62±2.23) ng/L in the control group,and the difference was significant (P<0.05). After treatment,the peak expiratory flow (PEF) of the study group was (68.79±4.49) L/min,the forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) was (71.38±5.23)％,and FVC was (2.58±0.33) L,which were higher than (66.21±4.55) L/min,(64.33±5.25)％,and (2.14±0.25) L of the control group,and the difference was significant (P<0.05). The overall effective rate of the study group was 96.67％,which was higher than 80.00％ of the control group,and the difference was significant (P<0.05). Conclusion The effect of acetylcysteine granule plus azithromycin in the treatment of mycoplasma pneumoniae pneumonia in children is significant,which can effectively inhibit inflammatory factors,improve lung function,shorten the time of symptom disappearance and duration of hospitalization,and has high promotion value.
Mycoplasma pneumoniae pneumonia in childrenAcetylcysteine granulesAzithromycinInflammatory factorsPulmonary function
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