Analysis of the incidence of frailty and its influencing factors in elderly patients with chronic obstructive pulmonary disease
Objective To investigate the occurrence of frailty in elderly patients with chronic obstructive pulmonary disease and analyze the influencing factors for frailty. Methods The clinical data of 230 elderly patients with chronic obstructive pulmonary disease were collected and assessed for frailty,and the occurrence of frailty was counted. Comparative analysis of clinical data between patients with and without frailty to understand the factors affecting frailty occurrence. Results 34 of 230 patients experienced frailty,with an incidence rate of 18.70％. There were no significant differences in gender,smoking history,drinking history,body mass index (BMI),white blood cell count (WBC),neutrophil count (NEUT) between patients with and without frailty (P>0.05). There were significant differences in age,residential status,disease severity,comorbidities,disease acceptance,depressive state,multiple drug use,hemoglobin (Hb),interleukin-6 (IL-6) between patients with and without frailty (P<0.05). With frailty as the dependent variable (non-frailty=0,frailty=1),age (<75 years=0,≥75 years=1),residential status (non-living alone=0,living alone=1),disease severity (mild to moderate=0,severe or above=1),comorbidities (no=0,yes=1),disease acceptance (good or complete acceptance=0,poor or unacceptable=1),depressive status (no=0,yes=1),multiple drug use (no=0,yes=1),IL-6 (<3 ng/L=0,≥3 ng/L=1),and Hb (≥115 g/L=0,<115 g/L=1) were assigned values for the independent variables and included in multifactorial Logistic regression analysis. Multivariate Logistic regression analysis showed that age ≥75 years old[OR=2.199,95％CI=(1.098,4.405)],severe or above disease severity[OR=2.478,95％CI=(1.244,4.938)],comorbidities[OR=5.583,95％CI=(2.157,14.450)],poor disease acceptance or unacceptable[OR=7.438,95％CI=(2.259,24.487)],depressive state[OR=5.109,95％CI=(2.017,12.942)],multiple drug use[OR=3.415,95％CI=(1.422,8.203)],IL-6≥3 ng/L[OR=1.283,95％CI=(1.098,1.499)]were risk factors for frailty in elderly patients with chronic obstructive pulmonary disease. Hb≥115 g/L[OR=0.556,95％CI=(0.312,0.991)]was a protective factor for frailty in elderly patients with chronic obstructive pulmonary disease (P<0.05). Conclusion The incidence of frailty in elderly patients with chronic obstructive pulmonary disease is relatively high,and there are many factors that lead to frailty. Clinical evaluation of patients should be actively carried out,and targeted interventions should be given to high-risk populations to help patients prevent and control frailty.
Chronic obstructive pulmonary diseaseFrailtyInfluencing factorsOld age
万方数据
维普
