The effect of metronidazole tablets combined with clindamycin phosphate vaginal gel on bacterial vaginitis
Objective To analyze the effect of metronidazole tablets combined with clindamycin phosphate vaginal gel on bacterial vaginitis. Methods 60 cases of bacterial vaginitis patients were selected as the study subjects,and they were divided into the control group and the observation group using the random numerical table,with 30 cases in each group. The control group received clindamycin phosphate vaginal gel treatment,and the observation group received metronidazole tablets combined with clindamycin phosphate vaginal gel treatment. The treatment effect,symptom disappearance time,symptom score,inflammatory factors,vaginal immune cell indicators,recurrence rate,and incidence of adverse reactions were compared between the two groups. Results The total effective rate of 93.33％ in the observation group was higher than 66.67％ in the control group,and the difference was statistically significant (P<0.05). The disappearance time of vaginal pain,vulvar pruritus and leukorrhea reduction were (3.11±0.25),(3.65±0.25) and (4.05±0.25) d in the observation group,which were shorter than (5.21±0.21),(5.68±0.12) and (6.68±0.34) d in the control group. The difference was statistically significant (P<0.05). After treatment,the symptom scores in both groups were lower than those before treatment in this group,and the symptom score of (9.54±1.21) points in the observation group was lower than (12.68±1.24) points in the control group. The difference was statistically significant (P<0.05). After treatment,interleukin-6 (IL-6),interleukin-4 (IL-4),and C-reactive protein (CRP) of the observation group were (51.28±1.21) pg/ml,(62.35±1.65) ng/ml,and (2.51±0.35) mg/dl,which were lower than (70.54±1.23) pg/ml,(86.54±1.52) ng/ml,and (3.98±0.42) mg/dl in the control group,and the difference was statistically significant (P<0.05). After treatment,the observation group had γ-interferon (IFN-γ) of (65.25±1.21) pg/ml and interleukin-12 (IL-12) of (200.51±10.65) pg/ml,which were lower than (74.69±1.65) and (220.25±6.38) pg/ml in the control group,and the difference was statistically significant (P<0.05). At 3-month follow-up,the recurrence rate of 3.33％ in the observation group was lower than 30.00％ in the control group,and the difference was statistically significant (P<0.05). The incidence rate of adverse reactions of 6.67％ in the observation group was slightly lower than 10.00％ in the control group,but the difference was not statistically significant (P>0.05). Conclusion Clinical treatment of bacterial vaginitis can be combined with metronidazole tablets on the basis of clindamycin phosphate vaginal gel,which can better control the body's inflammatory reaction,enhance the function of the vaginal immune cells,and promote symptom relief. This method has ideal efficacy,and can further reduce the chances of disease recurrence.
万方数据
维普
