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工业复杂噪声的暴露特征及其听力损失风险评估模型研究

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目的 研究工业复杂噪声(CIN)的暴露特征及其听力损失风险评估模型.方法 选择噪声危害严重或者近5年内发生过噪声聋的典型企业10~15家,每家企业的噪声接触岗位(等效A声级≥80 dB)全部纳入研究范围,每个噪声作业岗位至少选取3~5名工人(<3名则全部纳入)作为测量对象,总计纳入1200例作业人员.调查记录并分析作业人员发生噪声性听力损失(NIHL)的临床资料,进行单因素及多因素Logistic回归分析,并进行模型构建及预测效果的受试者工作特征曲线(ROC曲线)分析.结果 噪声强度≥95 dB(A)、峰度≥7、累积噪声暴露量(CNE)≥100 dB(A)·年及峰度修正CNE(CNE')≥105 dB(A)·年作业人员的NIHL检出率较噪声强度<95 dB(A)、峰度<7、CNE<100 dB(A)·年及CNE'<105 dB(A)·年者更高(P<0.05).不同年龄、性别、文化程度、婚姻状况、体质量指数(BMI)水平及有无糖尿病、高血压、吸烟、饮酒、高温暴露者的NIHL发生率对比差异无统计学意义(P>0.05).以NIHL为因变量,以噪声强度(<95 dB(A)=0;≥95 dB(A)=1)、峰度(<7=0;≥7=1)、CNE[<100 dB(A)·年=0;≥100 dB(A)·年=1]、CNE'[<105 dB(A)·年=0;≥105 dB(A)·年=1]为自变量,进行Logistic回归分析发现,噪声强度≥95 dB(A)、峰度≥7、CNE≥100 dB(A)·年、CNE'≥105 dB(A)·年均为作业人员发生NIHL的危险因素(OR=2.471、2.033、3.357、3.112>1,P<0.05).按照Logistic回归所得变量的回归系数以及常数项以构建作业人员NIHL的风险评估模型,主要公式是:Prob=ea/(1+ea)×100%,其中e是指数函数,而a=0.905×噪声强度[<95 dB(A)=0;≥95 dB(A)=1]+0.710×峰度(<7=0;≥7=1)+1.211×CNE[<100 dB(A)·年=0;≥100 dB(A)·年=1]+1.135×CNE'[<105 dB(A)·年=0;≥105 dB(A)·年=1]-8.933.对上述模型实施拟合程度检验,应用H-L检验发现,x2=3.671,P=0.530>0.05,表明此模型预测的风险几率和实际几率存在较佳拟合程度.通过ROC检验上述预测模型和NIHL产生的拟合效果显示,灵敏度为70.36%,特异度为74.66%,曲线下面积(AUC)为0.790[95%CI=(0.688,0.869);P=0.000<0.05],模型的Prob临界值为0.452.结论 CIN的暴露特征主要为噪声强度高、峰度高、CNE高及CNE'高,噪声强度≥95 dB(A)、峰度≥7、CNE≥100 dB(A)·年及CNE'≥105 dB(A)·年的NIHL检出率较高,均为作业人员发生NIHL的危险因素,将其构建风险评估模型的预测效果较好.
Exposure characteristics of complex industrial noise and its risk assessment model for hearing loss
Objective To study the exposure characteristics of complex industrial noise (CIN) and its risk assessment model for hearing loss. Methods 10-15 typical enterprises with serious noise hazards or noise deafness in the past 5 years were selected,and all noise-exposed positions (equivalent A-weighted sound level≥80 dB) in each enterprise were included in the study,and at least 3-5 workers (all included if<3 workers) in each noise-exposed position were selected as the measurement subjects,and a total of 1200 cases of workers were included. Conducted a survey to record and analyze clinical data on noise-induced hearing loss (NIHL) among workers,performed univariate and multivariate logistic regression analysis,and constructed a model and performed receiver operating characteristic (ROC) curve analysis on the predictive performance. Results The NIHL detection rates of workers with noise intensity ≥95 dB(A),kurtosis ≥7,cumulative noise exposure (CNE)≥100 dB(A)·year and kurtosis-corrected CNE (CNE') ≥105 dB(A)·year were higher than those with noise intensity<95 dB(A),kurtosis<7,CNE<100 dB(A)·year and CNE'<105 dB(A)·year (P<0.05). There was no statistically significant difference in the comparison of the incidence of NIHL among patients with different ages,gender,education levels,marital status,body mass index (BMI) levels and with or without diabetes,hypertension,smoking,alcohol consumption,and heat exposure (P>0.05). With NIHL as the dependent variable and noise intensity[<95 dB(A)=0;≥95 dB(A)=1],kurtosis (<7=0;≥7=1),CNE[<100 dB(A)·year=0;≥100 dB (A)·year=1],CNE'[<105 dB(A)·year=0;≥105 dB(A)·year=1]as independent variables,Logistic regression analysis was performed,and found that noise intensity ≥95 dB(A),kurtosis ≥7,CNE ≥100 dB(A)·year,and CNE'≥105 dB(A)·year were all risk factors for the occurrence of NIHL in the workers (OR=2.471,2.033,3.357,3.112>1,P<0.05). According to the regression coefficients of the variables obtained from the Logistic regression as well as the constant term in order to construct the risk assessment model of NIHL for the workers,the main formulas were:Prob=ea/(1+ea)×100%,where e was an exponential function,and a=0.905×noise intensity[<95 dB(A)=0;≥95 dB(A)=1]+0.710×kurtosis (<7=0;≥7=1)+1.211×CNE[<100 dB(A)·year=0;≥100 dB(A)·year=1]+1.135×CNE'[<105 dB(A)·year=0;≥105 dB(A)·year=1]-8.933. A fitting degree test was implemented for the above model,and the application of the H-L test revealed that x2=3.671,P=0.530>0.05,indicating that there was a better fit between the risk probabilities predicted by this model and the actual probabilities. ROC test of the above prediction model and the fitting effect generated by NIHL showed that the sensitivity was 70.36%,the specificity was 74.66%,and the area under the curve (AUC) was 0.790[95%CI=(0.688,0.869);P=0.000<0.05],the critical Prob value of the model was 0.452. Conclusion The exposure characteristics of CIN are mainly high noise intensity,high kurtosis,high CNE and high CNE',and noise intensity ≥95 dB(A),kurtosis ≥7,CNE ≥100 dB(A)·year and CNE'≥105 dB(A)·year are the risk factors for the occurrence of NIHL in workers,and the risk assessment model constructed by them has good predictive effect.

Complex industrial noiseExposure characteristicsNoise-induced hearing lossRisk assessment model

郑庆辉、曾为民、孙晓京

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518117 深圳市龙岗区坪地公共卫生服务中心职业健康部

工业复杂噪声 暴露特征 噪声性听力损失 风险评估模型

2024

中国实用医药
中国康复医学会

中国实用医药

影响因子:0.797
ISSN:1673-7555
年,卷(期):2024.19(23)