Comparison of therapeutic effects of continuous blood purification and intermittent hemodialysis in patients with severe renal failure
Objective To analyze the effects of intermittent hemodialysis (IHD) and continuous blood purification (CBP) in patients with severe renal failure. Methods 100 patients with severe renal failure were randomly divided into an observation group and a control group,with 50 cases in each group. The observation group was treated with CBP,and the control group was treated with IHD. Comparison was made on levels of inflammatory factors[C-reactive protein (CRP),interleukin-6 (IL-6)],acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ) scores,blood urea nitrogen (BUN),serum creatinine (Scr),mean arterial pressure (MAP),heart rate (HR),complications and quality of life between the two groups. Results After treatment,the observation group had CRP of (10.21±1.14) mg/L and IL-6 of (28.44±3.10) pg/ml,which were lower than (13.42±2.09) mg/L and (32.52±4.20) pg/ml in the control group,and the difference was significant (P<0.05). After treatment,the observation group had APACHE Ⅱ score of (14.84±2.65) points,BUN of (20.33±4.03) mmol/L,Scr of (277.47±41.20) μmol/L,MAP of (87.26±6.37) mm Hg (1 mm Hg=0.133 kPa),and HR of (115.02±10.76) beats/min,which were significantly higher than (18.69±2.90) min,(28.76±4.30) mmol/L,(378.94±45.64) μmol/L,(70.34±5.92) mm Hg,and (130.45±11.87) beats/min in the control group,and the difference was significant (P<0.05). The incidence of complications of 6.00％ in the observation group was lower than 20.00％ in the control group,and the difference was significant (P<0.05). After treatment,the daily life score of the observation group was (92.73±1.01) points,the fatigue score was (92.02±1.31) points,the sleep score was (93.11±1.03) points,the mental score was (90.26±1.57) points,and the appetite score was (92.04±1.33) points,which were higher than (86.42±2.38),(84.24±2.08),(88.92±2.19),(85.02±2.40),and (86.41±2.58) points in the control group,and the difference was significant (P<0.05). Conclusion Compared with IHD,CBP is more effective in the treatment of patients with severe renal failure,and it is worth applying.
Intermittent hemodialysisSevere renal failureContinuous blood purificationQuality of lifeComplicationsRenal function
万方数据
维普
