Analysis of the value of GeneXpert MTB/RIF in the early diagnosis of intestinal tuberculosis
Objective To study the reference value and guiding role of using GeneXpert Mycobacterium tuberculosis/Ri-fampin (GeneXpert MTB/RIF) to detect fecal samples in the early diagnosis of intestinal tuberculosis. Methods A total of 909 patients with suspected intestinal tuberculosis were selected as the research subjects. Stool samples from all patients were collected,and acid-fast bacillus smear test and GeneXpert MTB/RIF test were performed,respectively. With clinical comprehensive diagnosis results as the gold standard,the false positive rate and diagnostic efficiency of GeneXpert MTB/RIF detection and acid-fast bacillus smear test were compared. Results 909 patients were clinically diagnosed,of which 132 cases (14.52％) were positive and 777 cases (85.48％) were negative. GeneXpert MTB/RIF detected 133 positive cases,of which 3 cases were false positive,with a false positive rate of 2.26％ (3/133);acid-fast bacillus smear test detected 136 positive cases,of which 34 cases were false-positive,with a false positive rate of 25.00％ (34/136). The false-positive rate of GeneXpert MTB/RIF test was lower than that of acid-fast bacillus smear test,and the difference was statistically significant (P<0.05). The diagnostic accuracy,specificity and sensitivity of GeneXpert MTB/RIF detection were 99.45％ (904/909),99.61％ (774/777) and 98.48％ (130/132);the diagnostic accuracy,specificity and sensitivity of acid-fast bacillus smear test were 92.96％ (845/909),95.62％ (743/777) and 77.27％ (102/132). The diagnostic accuracy,specificity and sensitivity of GeneXpert MTB/RIF detection were higher than those of acid-fast bacillus smear test,and the difference was statistically significant (P<0.05). Conclusion In the early diagnosis of intestinal tuberculosis,the use of GeneXpert MTB/RIF to detect fecal samples has a high value,and is worthy of promotion and application.
万方数据
维普
