Analysis of clinical effect of alteplase intravenous thrombolysis combined with edaravone and dexborneol in the treatment of acute cerebral infarction
Objective To analyze the clinical value of alteplase intravenous thrombolysis combined with edaravone and dexborneol in the treatment of acute cerebral infarction. Methods 72 patients with acute cerebral infarction were selected as the study subjects and divided into a control group and an observation group by random number table method,with 36 cases in each group. The control group was treated with alteplase intravenous thrombolysis,and the observation group was treated with edaravone and dexborneol on the basis of the control group. The therapeutic effect,neurological deficit,activity of daily living and inflammatory factors before and after treatment were compared between the two groups. Results The total effective rate of 97.22％ in the observation group was higher than 83.33％ in the control group (P<0.05). Before treatment,there were no significant differences in National Institutes of Health Stroke Scale (NIHSS) and Activity of daily living (ADL) scores between the two groups (P>0.05). After 2 weeks of treatment,NIHSS score of (5.42±1.07) points in the observation group was lower than (8.06±1.28) points in the control group,ADL score of (79.69±8.07) points was higher than (65.38±7.59) points in the control group (P<0.05). Before treatment,there were no significant differences in serum C-reactive protein (CRP),tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels between the two groups (P>0.05). After 2 weeks of treatment,the observation group had serum CRP of (5.52±0.63) mg/L,TNF-α of (6.35±1.06) ng/L and IL-6 of (72.36±5.59) ng/L,which were lower than (6.79±0.75) mg/L,(8.97±1.15) ng/L and (89.59±6.37) ng/L in the control group (P<0.05). Conclusion Alteplase intravenous thrombolysis combined with edaravone and dexborneol can effectively inhibit inflammation,promote neurological recovery,and significantly improve clinical efficacy in patients with acute cerebral infarction.
Acute cerebral infarctionAlteplaseEdaravone and dexborneolIntravenous thrombolysis
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