Effect of magnesium aluminum carbonate combined with esomeprazole in the treatment of patients with gastric ulcer accompanied by gastric bleeding
Objective To explore the effect of magnesium aluminum carbonate combined with esomeprazole in the treatment of patients with gastric ulcer accompanied by gastric bleeding. Methods 72 patients with gastric ulcer accompanied by gastric bleeding as study subjects were divided into a control group (36 cases) and an observation group (36 cases) according to the order of admission. The control group was treated with esomeprazole,while the observation group was treated with magnesium aluminum carbonate combined with esomeprazole. The clinical efficacy,epidermal growth factor (EGF),vascular endothelial growth factor (VEGF),cyclooxygenase (COX) levels and adverse reactions of the two groups were compared. Results The total effective rate of the observation group was significantly higher than that of the control group (97.22％ VS 80.56％,P<0.05). There were no significant differences in EGF,VEGF and COX levels between the two groups before treatment (P>0.05). After treatment,the observation group had EGF of (286.71±6.14) ng/L,VEGF of (142.57±13.25) ng/L and COX of (41.37±7.14) U/L,which were higher than (242.58±6.82) ng/L,(115.64±12.12) ng/L and (26.48±7.35) U/L in the control group (P<0.05). The incidence of adverse reactions in the observation group was 5.56％,which was lower than 22.22％ in the control group (P<0.05). Conclusion Magnesium aluminum carbonate combined with esomeprazole is effective in the treatment of gastric ulcer accompanied by gastric bleeding,and the incidence of adverse reactions is low.
万方数据
维普
