Clinical effects of different doses of levothyroxine sodium tablets on pregnant women with hypothyroidism during pregnancy
Objective To explore the clinical effect of different doses of levothyroxine sodium tablets on pregnant women with hypothyroidism during pregnancy. Methods 100 patients with singleton and diagnosed hypothyroidism during pregnancy were selected as the study subjects. They were divided into a control group and a study group according to random numerical table,with 50 cases in each group. The control group was treated with low-dose levothyroxine sodium tablets,while the study group was treated with high-dose levothyroxine sodium tablets. Comparison was made on thyroid function[thyroid peroxidase antibody (TPO-Ab),free thyroxine (FT4),thyroid stimulating hormone (TSH)],incidence of adverse pregnancy outcomes,folic acid,ferritin,vitamin B12 level between the two groups. Results Before treatment,TPO-Ab of the control group was (43.37±3.28) IU/ml,FT4 was (6.76±0.14) pmol/L,and TSH was (4.69±0.52) mIU/L;TPO-Ab of the study group was (43.11±3.26) IU/ml,FT4 was (6.75±0.18) pmol/L,and TSH was (4.71±0.55) mIU/L. After treatment,TPO-Ab of the control group was (32.02±2.12) IU/ml,FT4 was (7.79±0.16) pmol/L,and TSH was (2.32±0.22) mIU/L;TPO-Ab of the study group was (27.31±2.17) IU/ml,FT4 was (9.98±0.53) pmol/L,and TSH was (1.73±0.23) mIU/L. Before treatment,there was no significant difference in TPO-Ab,FT4 and TSH levels between the two groups (P>0.05). After treatment,the levels of TPO-Ab and TSH decreased and FT4 increased in both groups compared with those before treatment;the levels of TPO-Ab and TSH in the study group were lower than those in the control group,and FT4 level higher than that in the control group;the difference was significant (P<0.05). After treatment,the levels of TPO-Ab and TSH decreased and FT4 increased in both groups,and the magnitude of change in the study group was better than that in the control group;the difference was significant (P<0.05). In the control group,there were 3 cases (6.00％) of premature births,4 cases (8.00％) of fetal distress and 3 cases (6.00％) of fetal growth restriction;in the study group,there were 2 cases (4.00％) of premature births,0 cases of fetal distress,and 1 case (2.00％) of fetal growth restrict ion. The incidence of adverse pregnancy outcome of 6.00％ in the study group was lower than 20.00％ in the control group (P<0.05). There was no significant difference in the levels of folic acid,ferritin and vitamin B12 between the two groups before and after treatment (P>0.05). Conclusion In the clinical treatment of hypothyroidism during pregnancy,high doses have a more significant effect on improving thyroid function than low doses,and can effectively prevent the occurrence of adverse pregnancy outcomes,the treatment can be used as a reference for clinical treatment.
Hypothyroidism during pregnancyLevothyroxine sodium tabletsDifferent dosesClinical effects
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维普
