目的 分析糖尿病肾病采取健脾泄浊解毒加减方治疗的临床效果.方法 选取100例糖尿病肾病患者,以随机抽签法分为对照组(n=50,采取常规治疗)和观察组(n=50,在对照组基础上采取健脾泄浊解毒加减方治疗).比较两组临床疗效、中医证候积分、实验室指标[24 h尿蛋白定量(24 h UPQ)、血肌酐(Scr)和尿素氮(BUN)].结果 观察组的治疗总有效率92.00％ 高于对照组的70.00％(P<0.05).治疗后,观察组浮肿积分(1.55±0.55)分、腰膝酸软积分(1.85±0.60)分、倦怠乏力积分(1.93±0.71)分均低于对照组的(2.82±0.67)、(2.51±0.72)、(2.49±0.85)分(P<0.05).治疗后,两组24 h UPQ、Scr、BUN水平均较治疗前下降,且观察组24 h UPQ(1.02±0.62)g/24 h、Scr(83.65±10.35)μmol/L、BUN(9.52±3.62)mmol/L均低于对照组的(2.10±0.86)g/24 h、(92.78±11.05)μmol/L、(11.48±3.17)mmol/L(P<0.05).结论 糖尿病肾病采取健脾泄浊解毒加减方治疗有着确切效果,能够减轻中医症状,促进肾功能改善.
Study on the effect of modified Jianpi Xiezhuo Jiedu Recipe in treating diabetes nephropathy
Objective To analyze the clinical effect of modified Jianpi Xiezhuo Jiedu Recipe in treating diabetes nephropathy. Methods 100 patients with diabetes nephropathy were divided into the control group (n=50,treated with conventional therapy) and the observation group (n=50,treated with modified Jianpi Xiezhuo Jiedu Recipe based on the control group) according to random lottery method. The clinical efficacy,traditional Chinese medicine syndrome score and laboratory indicators[24 h urinary protein quantification (24 h UPQ),serum creatinine (Scr) and blood urea nitrogen (BUN)]of the two groups were compared. Results The total effective rate of 92.00％ in observation group was higher than 70.00％ in the control group (P<0.05). After treatment,the observation group had edema score of (1.55±0.55) points,lumbar debility score of (1.85±0.60) points,and fatigue score of (1.93±0.71) points,which were lower than (2.82±0.67),(2.51±0.72),and (2.49±0.85) points in the control group (P<0.05). After treatment,24 h UPQ,Scr and BUN levels in both groups decreased compared with those before treatment;the observation group had 24 h UPQ of (1.02±0.62) g/24 h,Scr of (83.65±10.35) μmol/L and BUN of (9.52±3.62) mmol/L,which were lower than (2.10±0.86) g/24 h,(92.78±11.05) μmol/L and (11.48±3.17) mmol/L in the control group (P<0.05). Conclusion The treatment of diabetes nephropathy with modified Jianpi Xiezhuo Jiedu Recipe has a definite effect,which can alleviate the symptoms of traditional Chinese medicine and promote the improvement of renal function.
Modified Jianpi Xiezhuo Jiedu RecipeDiabetes nephropathyRenal function
万方数据
维普
