Analysis of the effect of hepatitis B vaccination on prevention and control of hepatitis B infection in infants
Objective To analyze the clinical effect of hepatitis B vaccination on prevention and control of hepatitis B infection in infants. Methods 1000 infants who had completed three doses of hepatitis B vaccination were randomly selected as the observation subjects. The titer and response of hepatitis B antibody were tested and compared at 1,2 and 3 years after vaccination. The positive conversion of surface antibodies were tested and compared at 4,12,and 24 weeks after the first vaccination,and different antibody levels were analyzed after vaccination. Results The hepatitis B antibody titer at 1,2 and 3 year after vaccination were (119.62±2.34),(90.46±1.57) and (49.91±1.27) mU/ml. The hepatitis B antibody titer at 1 year after vaccination was significantly higher than that at 2 and 3 years after vaccination,and the titer at 2 years after vaccination was significantly higher than that at 3 years after vaccination. There was statistical significance in comparison (P<0.05). The hepatitis B antibody response of at 1 year after vaccination was significantly better than that at 2 and 3 years after vaccination,and the response at 2 years after vaccination was better than that at 3 years after vaccination. There was statistical significance in comparison (P<0.05). The longer the follow-up time,the positive conversion of surface antibodies increased gradually,and here was statistical significance in comparison (P<0.05). The rate of positive conversion at 24 weeks after vaccination was 97.8％,which was higher than 51.4％ at 12 weeks after vaccination and 26.6％ at 4 weeks after vaccination;the rate of positive conversion at 12 weeks after vaccination was significantly higher than at 4 weeks after vaccination;there was statistical significance in comparison (P<0.05). Antibody levels in infants were tested after vaccination,and the results showed that A1 was (120.31±5.79) mIU/L,A3 was (150.62±8.04) mIU/L,and B antibody was (63.49±3.68) mIU/L after vaccination,and the levels were all higher. Conclusion Hepatitis B vaccination has a good preventive and control effect on hepatitis B infection in infants. It can reduce the infection rate to a large extent,and bring protection for the growth and development of infants,and the effect is remarkable,so it is a preventive and control measure worthy of active promotion.
InfantsHepatitis B vaccinationHepatitis BPrevention and control effect
万方数据
维普
