摘要
目的：探讨多项指标包括癌胚抗原（CEA）、P63蛋白、天门冬氨酸蛋白酶 A（Napsin A）联合在肺鳞癌与腺癌的病理学鉴别诊断中意义。方法分析我院自2011年1月至2013年1月收治的92例肺癌患者，其中鳞癌49例及腺癌43例，采用酶联免疫吸附法（ELISA）和免疫放射分析法（IRMA）检测 CEA、P63蛋白、Napsin A。结果①CEA 、P63蛋白、Napsin A 在鳞癌与腺癌中的阳性率显著不同，在统计学上具有显著性意义（P ＜0．05，0．005）。②腺癌转移癌中 P63蛋白阳性率在原发性、转移性中比较，在统计学上具有显著性差异（P ＜0．005）。③CEA、P63蛋白、Napsin A 三者联合检测腺癌的敏感性为95．9％，联合检测腺癌的敏感性为90．7％。结论CEA、P63蛋白、Napsin A三种肿瘤标志物用于病理学鉴别诊断肺腺癌与鳞癌，三者联合检测敏感性高，在检测肺癌中具有一定的应用价值。
Abstract
Objective To explore the meaning of the multi-combined indicators such as Carcinoembryonic antigen (CEA),P63 protein,aspartic proteinase A (Napsin A)in the pathological differential diagnosis of lung squamous carci-noma and adenocarcinoma.Methods We analyzed 92 cases who had lung cancer from January 2011 to January 2013,in-cluding 49 squamous carcinoma cases and 43 adenocarcinoma cases.The CEA,P63 protein,Napsin A levels were inspec-ted by ELISA and IRMA detection.Results ①There were significantly differences of the positive rates of CEA,P63 protein,Napsin A between squamous carcinoma and adenocarcinoma (P < 0.05,0.005).② There were significantly differences of the positive rates of metastatic adenocarcinoma cancer in case of the primary tumor and the metastatic tumor were compared (P <0.005).③The sensitivity of the application of combined CEA,P63 protein,Napsin A detec-tion for adenocarcinoma was 95.9%,while the sensitivity of the combined detection for adenocarcinoma was 90.7%. Conclusion When the three tumor markers of CEA,p63 protein and Napsin A are employed in pathological differential diagnosis lung adenocarcinoma and squamous cell carcinomas,the sensitivity of the combined detection is high and of applicable meanings in the detection of lung cancer.
NETL
NSTL
维普
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