Detection of mini chromosome maintenance 5 protein in bladder carcinoma tissue and urine exfoliate cells
Objective To explore the expression and clinical significance of tiny chromosome maintenance protein (MCM)in bladder cancer tissue and urine exfoliated cells.Methods Urinary exfoliated cells or tissues of the bladder of hospitalized patients and healthy volunteers in our hospital from August 2012-August 2013 were collected,and the urine exfoliated cells or tumor tissue MCM5 was tested.Results ① The difference was statistically significant of clinical stagebladder cancer patients in different pathological grading MCM/β-actin (P < 0.05).② There were 71 cases with MCM5 positive in 80 bladder cancer patients with urinary exfoliated cells,differences between bladder cancer group and Normal control group or other urinary diseases group were statistically significant (P <0.05).③compared to urine cy-tology,sensitivity and negative predictive value of urine exfoliated cells MCM5 detection and diagnosis of bladder cancer was significantly higher,false-negative rate was significantly lower ,the difference was statistically significant (P <0.05),There was no statistical significance difference in specific degree,false positive rate and positive predictive value (P >0.05).Conclusion Diagnosis of MCM5 in urine exfoliated cells to detect bladder cancer have a greater sense,it is a recurrence of bladder cancer detection,prognosis better indicator,it is worth widely used in clinical diagnosis.
NETL
NSTL
万方数据
维普
