Objective To study the protein expression of ZNF23 in lung cancer and its relationgship with clinico-pathological.Methods The expression of znic finger ZNF23 in human non-small cell lung cancer was tested by immu-nohistochemistry.ZNF23 protein and mRNA expression in NSCLC tissues and normal tissues was examined by western blot and real-time PCR.In addition we also explored the association of ZNF23 with cell cycle progression in lung cancer cell lines.Results ZNF23 mRNA and protein levels were significantly lower in the tumor tissues compared to the adja-cent normal tissues in Non-Small Cell Lung Cancer.There was a close correlation between ZNF23 down-regulation and TNM stage,differentiation,histology,tumor status and nodal status.Downregulation of ZNF23 by siRNA can induce the cell cycle in S/G2.Conclusion ZNF23 is found to be a tumor inhibitor which is downexpressed in Non-Small Cell Lung Cancer.ZNF23 inhibits cell growth by inducing cell cycle arrest in Non-Small Cell Lung Cancer cells.
ZNF23zinc-finger proteinscell cycle progressionNon-Small Cell Lung Cancer
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NSTL
维普
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