Objective To explore the predictive value of early postoperative pain trajectory in postoperative persis-tent pain in breast cancer.Methods The clinical data of breast cancer patients treated in Department of Anesthesiology,Dongfang Hospital to Tongji University hospital from January 2019 to December 2021 were analyzed retrospectively.GBTM was used to model and analyze the intergroup pain intensity according to the pain intensity of 1～7 days after operation to determine the early postoperative pain trajectory.Logistic regression model was used to analyze the correla-tion between early postoperative pain trajectory and persistent pain 6 months after operation.ROC curve was used to e-valuate the predictive value of early postoperative pain trajectory in postoperative persistent pain in patients with breast cancer.Results Three groups of models(mild,moderate and severe pain)were suitable for analyzing the early postop-erative pain trajectory.Six months after operation,the incidence of pain was 50.80％,of which 42.24％had moderate pain and 8.55％had severe pain.The common sites of pain were chest(39.57％),armpit(27.81％),arm(13.91％)and back(7.49％).The track of severe pain in early postoperative pain was related to persistent pain 6 months after opera-tion(P＜0.001).ROC curve showed that the AUC of severe pain trajectory to predict the degree of persistent pain after breast cancer operation was 0.865.Conclusion The early postoperative pain trajectory can be used to predict persistent pain after breast cancer operation.patients can be classified according to the early postoperative pain trajectory and tar-geted intervention measures can be taken.
postoperative acute painbreast cancer surgeryoutpatient surgerypostoperative persistent painpost-operative pain trajectory
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