Analysis of risk factors for the occurrence of different subtypes of early-stage adenocarcinoma of the esophagogastric junc-tion and precancerous lesions
Objective To explore the risk factors for the occurrence of different subtypes of early-stage adenocarci-noma of the esophagogastric junction(AEG)and precancerous lesions.Methods A total of 128 patients diagnosed with early-stage AEG and precancerous lesions,confirmed through gastroscopy and pathology,between January 2018 and January 2023 at Jincheng City People's Hospital were selected as the study group.A control group of 128 healthy indi-viduals who underwent physical examinations during the same period was included.The early-stage AEG and precancer-ous lesion patients were classified into two subtypes,namely type Ⅱ and type Ⅲ,according to the Siewert classification.Independent risk factors for the occurrence of different subtypes of early-stage AEG and precancerous lesions were ana-lyzed.Results The average age of patients with early-stage AEG and precancerous lesions was 65.68 years,with a male-to-female ratio of 5.1:1.Atrophy/intestinal metaplasia(OR=8.89,95％CI 4.85～16.29)and family history of tumors(OR=5.07,95％CI 1.70～15.15)were identified as independent risk factors for the occurrence of early-stage AEG and precancerous lesions(P＜0.05).Atrophy/intestinal metaplasia and family history of tumors were identified as common independent risk factors for the occurrence of type Ⅱ and type Ⅲ early-stage AEG and precancerous lesions(P＜0.0 5).Conclusion Elderly males with atrophy/intestinal metaplasia and a family history of tumors are more sus-ceptible to early-stage AEG and precancerous lesions.There is no difference in the risk factors for the occurrence of typeⅡ and type Ⅲ early-stage AEG and precancerous lesions.Additionally,there is no difference in the risk factors for the occurrence of early-stage AEG and precancerous lesions.
early-stage adenocarcinoma of the esophagogastric junctionprecancerous lesionsSiewert classificationrisk factors
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