Objective Analyze the correlation between serum and nutritional indicators and the prognosis of patients with old thoracolumbar fractures,and evaluate the experimental study of nutritional intervention on patient prognosis.Methods 60 patients with old thoracolumbar fractures treated by artificial vertebral replacement in our hospital from January 2019 to January 2023 were divided into poor prognosis group and good prognosis group according to their prog-nosis.The levels of prealbumin(PA),hemoglobin(HB),transferrin(TF),albumin(ALB),total protein(TP),creatinine(Cr),lymphocyte(LYM)and blood calcium in the two groups were measured,and the prognostic nutritional index(PNI)was calculated.Results the levels of PA,HB,TF,ALB,TP,LYM,blood calcium and PNI in the poor prognosis group were lower than those in the good prognosis group.Logistic regression analysis showed that HB,ALB,TF,LYM,blood calcium and PNI were independent risk factors for poor prognosis(OR=0.476~3.272,P=0.000~0.042,95%CI=0.269~4.117).ROC curve analysis showed that ALB,TF,LYM,blood calcium and PNI were 0.668,0.750,0.718,0.641,0.865,The sensitivity and specificity of PNI in predicting poor prognosis were 86.89%and 82.77%.Conclu-sion Serological indicators and patient nutritional status are closely related to the prognosis of patients with old thora-columbar fractures,and can be used as important prognostic indicators for patients.