208例耐药结核病患者耐药特征分析
Analysis of drug resistance characteristics in 208 cases of drug-resistant tuberculosis
马志强 1陈薇 1王晓燕 1李才信 1李晓琴 1王霖1
作者信息
- 1. 昆明市第三人民医院检验科,云南昆明 650301
- 折叠
摘要
目的 为了解耐药结核病患者的耐药特征.方法 收集2021年9月至2022年9月昆明市第三人民医院结核科收治的208例耐药结核病患者的实验室资料为研究对象,分析其在不同年龄、性别、标本类型、抗结核药物耐药中的占比情况.结果 208例研究对象中.各年龄段耐药青少年5例(2.40％),青年97例(46.64％),中年70例(33.65％),老年36例(17.31％);不同性别中男性130例(62.50％),女性78例(37.50％).各抗结核药物中单耐药97例(46.63％),多耐药22例(10.58％),耐多药89例(42.79％);单耐药中耐异烟肼最多,为51例(24.52％),其次为耐利福平24例(11.54％).各标本耐药中痰液110例(52.89％),灌洗液83例(39.90％),脓液7例(3.37％),胸水3例(1.44％)、支刷物3例(1.44％)、脑脊液2例(0.96％).结论 耐药结核病患者以异烟肼为代表的单耐药为主,耐多药次之,不同人群中青年和男性耐药多见,各标本中痰液标本耐药占比最多.应注意耐药结核病患者检测及诊疗工作.
Abstract
Objective To understand the drug resistance characteristics of drug-resistant TB patients.Methods The laboratory data of 208 drug-resistant TB patients admitted to the tuberculosis department of the Third Peoples Hospital of Kunming from September 2021 to September 2022 as study subjects,and analyzed their proportions in different ages,genders,specimen types,and anti-tuberculosis drug resistance.Results It was found that among 208 study subjects.5 cases(2.40％)were adolescents,97 cases(46.64％)were youths,70 cases(33.65％)were middle-aged and 36 cases(17.31％)were elderly among all ages of drug resistance;There were 130 cases(62.50％)of males and 78 cases(37.50％)of females by gender.97 cases(46.63％)were mono-resistant,22 cases(10.58％)were multi-resistant and 89 cases(42.79％)were multidrug-resistant among various anti-tuberculosis drugs;among the monoresistant cases,51 cases(24.52％)were the most resistant to isoniazid,followed by 24 cases(11.54％)rifampicin-resistant cases.Among the specimens resistant to each drug were sputum in 110 cases(52.89％),lavage fluid in 83 cases(39.90％),pus in 7 cases(3.37％),pleural fluid in 3 cases(1.44％),branch brushings in 3 cases(1.44％),and cerebrospinal fluid in 2 cases(0.96％).Conclusion Patients with drug-resistant tuberculosis are dominated by isoniazid as the representative of sin-gle drug resistance,and multi-drug resistance is second,and drug resistance is more common among young people and men in different populations,and the detection in each specimen,Sputum specimens accounted for the largest proportion of drug resistance among all specimens,Attention should be paid to the detection and treatment of drug-resistant tuber-culosis patients.
关键词
结核病/耐药特征/分析Key words
tuberculosis/drug resistance characteristics/analysis引用本文复制引用
基金项目
国家自然科学基金(82260408)
云南省教育厅科研项目(2022J0725)
昆明市卫生健康委卫生科研课题(2022-11-01-011)
昆明市卫生健康委卫生科研课题(2022-11-01-004)
昆明市卫生科技人才培养"千"工程后备人选项目(2019-sw后备-25)
昆明市卫生科技人才培养"千"工程后备人选项目(2020-SW后备-60)
昆明市卫生科技人才培养"千"工程后备人选项目(2022-SW后备-70)
昆明市卫生科技人才培养"千"工程后备人选项目(2022-SW后备-85)
出版年
2024
NETL
NSTL
万方数据