Objective To analyze the correlation between the levels of C-reactive protein/albumin(CRP/ALB)and soluble interleukin-2 receptor(sIL-2R)and the severity and prognosis of neonatal pulmonary infection.Methods A to-tal of 120 neonates with pulmonary infection were selected from June 2019 to June 2022.CRP,ALB and sIL-2R levels were measured in all children,and CRP/ALB was calculated.All neonates were cultured with pathogenic bacteria from lung secretions and divided into bacterial infection group and non-bacterial infection group according to whether it was bacterial infection.According to the severity of the disease,they were divided into mild infection group and severe infec-tion group.The levels of CRP/ALB and sIL-2R in neonates of bacterial infection group and non-bacterial infection group,mild infection group and severe infection group were compared.According to the therapeutic effect after 2 weeks of neonatal treatment,the children were divided into good prognosis group and poor prognosis group.The levels of CRP/ALB and sIL-2R in children with different prognosis and clinical data were compared.Logistic regression analysis was used to determine the factors affecting the prognosis of neonates with pulmonary infection.Receiver operating char-acteristic curve(ROC)was used to analyze the predictive value of CRP/ALB and sIL-2R levels on the prognosis of neo-nates with pulmonary infection.Results Compared with non-bacterial infection group,CRP/ALB and sIL-2R levels in bacterial infection group were increased(P＜0.05).Compared with non-bacterial infection group,CRP/ALB and sIL-2R levels in bacterial infection group were increased(P＜0.05).Among 120 neonates with pulmonary infection,83 cases had good prognosis,37 cases had poor prognosis,and the poor prognosis rate was 30.83％.Compared with poor prog-nosis group,CRP/ALB and sIL-2R levels were increased in poor prognosis group(P＜0.05).The proportion of birth weight,Apgar score ≤7,cesarean section,neonatal distress,non-breastfeeding and invasive operation in poor prognosis group were higher than those in good prognosis group,but lower than those in good prognosis group(P＜0.05).Logis-tic regression model analysis showed that Apgar score ≤7,CRP/ALB and sIL-2R were independent risk factors for poor prognosis of neonates with pulmonary infection(P＜0.05).ROC analysis results showed that the AUC(95％CI)of CRP/ALB and sIL-2R alone and combined in predicting poor prognosis of newborns with pulmonary infection were 0.764(0.678～0.817),0.710(0.620～0.789)and 0.862(0.787～0.918),respectively.The predictive efficacy of CRP/ALB combined with sIL-2R was higher than that of SIL-2R alone(Z=1.953,2.213,P＜0.05).Conclusion The levels of CRP/ALB and sIL-2R were abnormally elevated in neonates with severe pulmonary infection.High levels of CRP/ALB and sIL-2R are independent risk factors for poor prognosis of neonates with pulmonary infection,and their combi-nation has high predictive value for poor prognosis of neonates with pulmonary infection.
Pulmonary infectionC-reactive protein/albuminSoluble interleukin-2 receptorThe severity of the ill-nessPrognosis
NETL
NSTL
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