首发精神分裂症患者血清泌乳素水平与言语性幻听、认知功能受损的相关性研究
Study on the correlation between serum prolactin level and speech auditory hallucinations and cognitive impairment in first-episode schizophrenia
任静 1李迎晨 1梁曼丽 1陈长浩1
作者信息
- 1. 宿州市第二人民医院精神科,安徽宿州 234000
- 折叠
摘要
目的 探讨首发精神分裂症(FES)患者血清泌乳素(PRL)水平与言语性幻听、认知功能受损的关系.方法 选取2021年1月至2023年12月期间宿州市第二人民医院收治的123例未治疗的FES患者,根据PRL检测水平分为正常PRL组(n=72),和高PRL组(n=51).比较不同性别正常PRL组与高PRL组一般资料、阳性与阴性症状量表(PANSS)症状、言语性幻听[中文版精神症状评定量表-幻听分量表(PSYRATS-AH)]及认知功能[认知功能蒙特利尔认知评估量表(MoCA)],采用Pearson相关性分析未治疗FES患者PSYRATS-AH总分、MoCA总分与血清PRL水平的关系.结果 高PRL组甘油三酯(TG)水平高于正常PRL组(P＜0.05).与正常PRL组相比,高PRL组阳性症状、阴性症状、一般精神病理及PANSS总分较高(P＜0.05);与正常PRL组男性相比,高PRL组男性阴性症状评分较高(P＜0.05).与正常PRL组相比,高PRL组PSYRATS-AH总分较高,MoCA总分较低(P＜0.05);与正常PRL组男性相比,高PRL组男性MoCA总分较低(P＜0.05),而与正常PRL组女性相比,高PRL组女性PSYRATS-AH总分较高(P＜0.05).多因素Logistic回归模型分析结果显示,PSYRATS-AH总分、MoCA总分是影响血清PRL升高的独立危险因素(P＜0.05).Pearson相关性分析显示,男性FES患者血清PRL与MoCA总分成负相关(r=-0.532,P＜0.001),女性 FES 患者血清 PRL 与 PSYRATS-AH 总分成正相关(r=0.501,P＜0.001).结论 未治疗FES患者体内血清PRL异常高表达,与言语性幻听及认知功能受损关系密切.
Abstract
Objective To investigate the relationship between serum prolactin(PRL)level,auditory hallucinations and cognitive impairment in patients with first-episode schizophrenia(FES).Methods 123 untreated FES patients ad-mitted to Department of psychiatry,second people's hospital of suzhou city hospital from January 2021 to December 2023 were selected and divided into normal PRL group(n=72)and high PRL group(n=51)according to the level of PRL detection.General data,Positive and negative Symptom Scale(PANSS)symptoms,verbal auditory hallucinations[PSYRATS-AH]and cognitive function[Montreal Cognitive Assessment Scale of Cognitive Function(MoCA)]were compared between normal and high PRL groups of different genders.Pearson correlation was used to analyze the rela-tionship between PSYRATS-AH total score,MoCA total score and serum PRL level in untreated FES patients.Results The level of triglyceride(TG)in high PRL group was higher than that in normal PRL group(P＜0.05).Compared with normal PRL group,positive symptoms,negative symptoms,general psychopathology and total score of PANSS in high PRL group were higher(P＜0.05).Compared with the normal PRL group,the men with high PRL had higher negative symptom scores(P＜0.05).Compared with normal PRL group,the total score of PSYRATS-AH was higher and the total score of MoCA was lower in high PRL group(P＜0.05).Compared with the normal PRL group,the total score of MoCA in the high PRL group was lower(P＜0.05),and the total score of PSYRATS-AH in the high PRL group was higher than that in the normal PRL group(P＜0.05).Multivariate Logistic regression model showed that the total score of PSYRATS-AH and the total score of MoCA were independent risk factors for the increase of serum PRL(P＜0.05).Pearson correlation analysis showed that serum PRL in male patients with FES was negatively correlated with MoCA(r=-0.532,P＜0.001),and serum PRL in female patients with FES was positively correlated with PSYRATS-AH(r=0.501,P＜0.001).Conclusion Abnormal high expression of serum PRL in untreated FES patients is closely related to speech auditory hallucinations and impaired cognitive function.
关键词
首发精神分裂症/泌乳素/言语性幻听/认知功能受损Key words
first-episode schizophrenia/prolactin/verbal auditory hallucinations/impaired cognitive function引用本文复制引用
基金项目
安徽省自然科学基金(2020)(2008085QH407)
出版年
2024
NETL
NSTL
万方数据