The effect of the DASH diet pattern on the levels of serum inflammatory factors and endothelial markers in middle-aged and elderly patients with hypertension
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目的 研究旨在探讨在DASH饮食(终止高血压膳食疗法,Dietary Approaches to Stop Hypertension)模式下对中老年高血压患者的血清炎症因子和内皮标志相关指标的影响.方法 研究分析了 87例常规饮食患者和90例DASH饮食患者的临床资料.比较两组营养摄入量、血清炎症因子(TNF-α、IL-6、CRP、IL-1β、MCP-1)和内皮标志物(内皮素-1、一氧化氮、VCAM-1、ICAM-1).并对其进行相关性分析.结果 与普通饮食组相比,DASH饮食组患者的总热量、总脂肪、饱和脂肪酸和钠摄入量较低,钾摄入量较高.DASH饮食组TNF-α和MCP-1水平较低,IL-6和IL-1β水平较高.内皮功能指标显示,DASH饮食组一氧化氮升高,内皮素-1水平降低,差异有统计学意义.相关分析显示饮食成分与炎症标志物和内皮功能指标之间存在关联.结论 研究为血清炎症因子和内皮功能指标用于评价DASH饮食对中老年高血压患者的影响提供了强有力的证据.
Objective The study aims to explore the effect on the serum inflammatory factors and endothelial mark-er-related indicators of middle-aged and elderly hypertension patients under the DASH diet(Dietary Approaches to Stop Hypertension).Methods The retrospective cohort study analyzed clinical data from 87 patients on a regular diet and 90 patients on the DASH diet.A comparison was made between the two groups in terms of nutritional intake,serum in-flammatory markers(TNF-α,IL-6,CRP,IL-1β,MCP-1),and endothelial function markers(endothelin-1,nitric oxide,VCAM-1,ICAM-1).Correlation analysis was also performed.Results Compared to the regular diet group,patients on the DASH diet had lower total energy intake,total fat,saturated fatty acids,and sodium intake,and higher potassium intake.The DASH diet group showed lower levels of TNF-α and MCP-1,and higher levels of IL-6 and IL-1β.Endotheli-al function markers revealed an increase in nitric oxide and a decrease in endothelin-1 levels in the DASH diet group.Correlation analysis indicated an association between dietary components and inflammatory markers as well as endothe-lial function markers.Conclusion This study demonstrates that the DASH diet,as a non-pharmacological approach,has the potential to regulate the inflammatory pathway and improve endothelial health in middle-aged and elderly patients with hypertension.
DASH dietmiddle-aged and elderlyhypertensionserum inflammatory factorsvascular endothelial function markers
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