Objective To explore the expression level and significance of secreted immunoglobulin A(sIgA),Meth-ylenedioxyamphetamine(MDA)and matrix metalloprotein-9(MMP-9)in the saliva of severe young children.Methods The 210 children with severe low childhood caries admitted to our hospital from April 2021 to April 2022,and 100 chil-dren in mild caries group and 110 children in healthy group were selected.The expressions of sIgA,MDA and MMP-9 in the three groups were examined by immunotransmission turbidimetry,ELISA,and the significance of changes in sI-gA,MDA and MMP-9 expression for caries in severe younger children was analyzed.Results Compared with healthy children,sIg A and MMP-9 expression were increased compared with healthy children,and severe children had increased sIg A,MMP-9 expression and decreased MDA levels(P＜0.05).Salivary MDA was negatively associated with the de-cayed-missing-filled surface(dmfs)index,while sIgA and MMP-9 were positively associated with the dmfs index(P＜0.05).The Pearson correlation analysis between sIg A,MDA,and MMP-9 showed a negative correlation between sIg A and MDA(r=-0.432,P=0.001),a positive correlation between sIgA and MMP-9(r=0.436,P=0.001),and a nega-tive correlation between MDA and MMP-9(r=-766,P=0.001).Conclusion The levels of sIgA,MMP-9 and MDA are increased in children with the presence of caries at severe age.
saliva of severe young children with cariesSecretory immunoglobulin AMalondialdehydeMatrix met-alloproteinase-9
NETL
NSTL
万方数据
