Objective Exploring the changes and clinical bignificance of peripheral blood lymphocyte subset count levels in lung cancer patients.Methods A total of 190 patients with lung cancer admitted to Changchun Cancer Hospi-tal from January 2021 to December 2021 were collected,and 24 healthy people who underwent physical examination during the same period were selected as the control group.Flow cytometry was used to detect the absolute count and percentage of peripheral blood lymphocyte subsets(including CD3+,CD3+CD4+,CD3+CD8+,CD3-CD19+and CD3-CD56+),and to analyze the differences in lymphocyte subsets between lung cancer patients and healthy people,different pathological types and different clinical stages of lung cancer patients.Results The absolute count of lymphocyte sub-sets in lung cancer patients was lower than that in healthy people(P＜0.05),the percentage of CD3 and CD3 CD4+T cells was lower than that in healthy people,and the percentage of CD3+CD8+T cells was higher than that in healthy people(P＜0.05).The absolute count level of lymphosubsets in NSCLC patients was significantly higher than that in small cell lung cancer(P＜0.05),and the percentage of CD3+was lower than that in healthy people and small cell lung cancer patients,while the percentage of CD3-CD56+was higher than that in healthy people and small cell lung cancer patients(P＜0.05).With the progression of clinical stage,the percentage of CD3+cells and CD3+CD4+T cells showed a decreasing trend in non-small cell lung cancer(P＜0.05),and there was no difference in small cell lung cancer.Con-clusion The immune function of lung cancer patients is weaker than that of healthy people,and the degree of immune function weakening increases with the progression of lung cancer stage.The immune function weakening of non-small cell lung cancer patients is mainly caused by T lymphocyt-led cellular immune function,while the immune function weakening of small cell lung cancer patients is more significant by NK natural killer cell function.
维普
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