Diagnostic values of serum MG7-Ag level and tissue Notch-3 level in gastric cancer
Objective To analyze the diagnostic value of serum levels of gastric cancer-associated antigen 7(MG7-Ag)and tissue levels of neurogenic locus notch homolog protein 3(Notch-3)in gastric cancer.Methods A retrospec-tive analysis was conducted on the clinical data of 23 patients with gastric cancer(gastric cancer group)and 50 patients with benign gastric lesions(benign lesion group)treated at the Second Medical Center of PLA General Hospital be-tween January and December 2023.The baseline data,serum MG7-Ag levels,and tissue Notch-3 levels of the patients in two groups were recorded.The influencing factors of gastric cancer,as well as the diagnostic performance of serum MG7-Ag levels and tissue Notch-3 levels for gastric cancer were analyzed.The serum MG7-Ag levels and tissue Notch-3 levels of the patients with different gastric cancer characteristics were compared,and the relationship between these levels and pathological parameters of gastric cancer(tumor size,TNM stage,vascular invasion,lymph node metastasis)was assessed.Results The serum pepsinogen Ⅰ(PG1)level of the patients in gastric cancer group was lower than that in benign lesion group,while the level of gastrin,carcinoembryonic antigen(CEA),MG7-Ag,and tissue Notch-3 of the patients were higher than those in benign lesion group(P＜0.05).The multivariate Logistic regression analysis results showed that gastrin(95％CI:1.033～1.112),CEA(95％CI:1.882～5.076),MG7-Ag(95％CI:1.649～4.443),and Notch-3(95％CI:1.639～4.219)were the risk factors for gastric cancer,while PG1(95％CI:0.880～0.984)was a protective factor(P＜0.05).The receiver operating characteristic(ROC)curve analysis results revealed that the sensi-tivities of serum MG7-Ag level,tissue Notch-3 level,and their combined diagnosis of gastric cancer were 73.90％,73.00％,and 91.30％,respectively.while the specificities were 86.00％,82.00％,and 80.00％,respectively.The area under the curve(AUC)for the combined diagnosis(0.958)was significantly higher than that for the individual indica-tors(P＜0.05).The patients with gastric cancer who had tumor diameters＞3 cm,stage Ⅲ～Ⅳ,vascular invasion,or lymph node metastasis had higher serum MG7-Ag level and tissue Notch-3 level compared with those with tumor diam-eters ≤3 cm,stage Ⅰ～Ⅱ,no vascular invasion,or no lymph node metastasis(P＜0.05).The Pearson correlation a-nalysis results indicated that the serum MG7-Ag level and tissue Notch-3 level were positively correlated with the tumor size,TNM stage,vascular invasion,and lymph node metastasis(P＜0.05).Conclusion The serum MG7-Ag lev-el and tissue Notch-3 level are elevated in the patients with gastric cancer,and these levels are positively correlated with the tumor size,TNM stage,vascular invasion,and lymph node metastasis.The combination of these two markers pro-vides a high diagnostic value for gastric cancer.
gastric cancer-associated antigen 7neurogenic locus notch homolog protein 3carcinoembryonic anti-gengastric neoplasmdiagnosis
万方数据
维普
