摘要
目的 探讨类黏蛋白1样蛋白3(ORMDL3)、胸腺基质淋巴细胞生成素(TSLP)与过敏性鼻炎患儿辅助性T淋巴细胞Th1/Th2平衡相关性及预测病情程度的价值.方法 回顾性分析2021年4月至2023年4月在北京市大兴区人民医院接受治疗的226例过敏性鼻炎患儿的病历资料,根据过敏性鼻炎严重程度分为轻度组144例和中重度组82例,比较两组的ORMDL3、TSLP及Th1/Th2水平,分析ORMDL3、TSLP与过敏性鼻炎患儿Th1/Th2平衡相关性,以及过敏性鼻炎患儿病情严重程度的影响因素.评估ORMDL3、TSLP对过敏性鼻炎患儿病情程度的预测价值.结果 轻度组和中重度组患儿的Th1/Th2分别为(1.61±0.54)、(0.89±0.27),ORMDL3 mRNA分别为(1.34±0.32)、(2.06±0.65),血清 TSLP 分别为(30.42±4.59)mg/mL、(32.08±5.67)mg/mL,差异有统计学意义(P＜0.05)o ORMDL3、TSLP 与 Th1、Th1/Th2 呈负相关(P＜0.05),与 Th2 呈正相关(P＜0.05).ORMDL3(OR=4.963,95％CI:1.762～13.979)、TSLP(OR=3.995,95％CI:1.418～11.252)是中重度过敏性鼻炎的危险因素(P＜0.05).ORMDL3、TSLP单一及联合预测中重度过敏性鼻炎的灵敏度分别为0.83、0.72、0.91,特异度分别为0.77、0.79、0.72,曲线下面积分别为0.779、0.731、0.874.结论 ORMDL3、TSLP与Th1/Th2呈负相关,能够预测过敏性鼻炎患儿的病情严重程度.
Abstract
Objective To explore the correlation between mucin like protein 3(ORMDL3),thymic stromal lympho-poietin(TSLP),and helper T lymphocyte Th1/Th2 balance in children with allergic rhinitis,and the value of predicting disease severity.Methods A retrospective analysis was conducted on the medical records of 226 children with allergic rhinitis who received treatment in hospitals from April 2021 to April 2023.According to the severity of allergic rhinitis,144 cases were divided into a mild group and 82 cases into a moderate to severe group.The levels of ORMDL3,TSLP,and Th1/Th2 were compared between the two groups.The correlation between ORMDL3,TSLP,and Th1/Th2 balance in children with allergic rhinitis was analyzed,as well as the influencing factors of the severity of allergic rhinitis in chil-dren.Evaluate the predictive value of ORMDL3 and TSLP for the severity of allergic rhinitis in children.Results The Th1/Th2 levels in the mild and moderate to severe groups were(1.61±0.54)and(0.89±0.27),respectively.TheORMDL3 mRNA levels were(1.34±0.32)and(2.06±0.65),respectively.The serum TSLP levels were(30.42±4.59)mg/mL and(32.08±5.67)mg/mL,respectively,with statistically significant differences(P＜0.05).ORMDL3 and TSLP are negatively correlated with Th1 and Th1/Th2(P＜0.05),and positively correlated with Th2(P＜0.05).ORMDL3(OR=4.963,95％CI:1.762～13.979)and TSLP(OR=3.995,95％CI:1.418～11.252)are risk factors for moderate to severe allergic rhinitis(P＜0.05).The sensitivity of ORMDL3 and TSLP single and combined predic-tion for moderate to severe allergic rhinitis were 0.83,0.72,and 0.91,respectively,with specificity of 0.77,0.79,and 0.72.The area under the curve was 0.779,0.731,and 0.874,respectively.Conclusion ORMDL3,TSLP,and Th1/Th2 are negatively correlated and can predict the severity of allergic rhinitis in children.
维普
万方数据