The predictive value of serum CXCL10 combined with high-resolution CT imaging features for severe mycoplasma pneumo-nia in children
Objective To explore the predictive value of serum CXC chemokine ligand 10(CXCL10)combined with high-resolution CT imaging features for severe mycoplasma pneumonia in children.Methods 126 patients with severe Mycoplasma pneumoniae pneumonia who received treatment in hospitals from April 2021 to April 2024 were selected.According to whether the patients had secondary respiratory failure,obstructive bronchitis,pulmonary fibrosis,dissemi-nated intravascular coagulation,death and other adverse prognoses within one month of treatment,they were divided in-to poor prognosis group and good prognosis group.The serum CXCL10 levels and high-resolution CT imaging charac-teristics of the two groups were compared,and the impact of serum CXCL10 levels and high-resolution CT imaging characteristics on the prognosis of severe Mycoplasma pneumoniae pneumonia patients was analyzed.The predictive value of serum CXCL10 combined with high-resolution CT imaging characteristics on the adverse prognosis of severe Mycoplasma pneumoniae pneumonia patients was evaluated.Results Among 126 patients with severe mycoplasma pneumonia,28 had poor prognosis,with an incidence rate of 22.22％.The lung percussion dullness,C-reactive protein(CRP),procalcitonin(PCT),white blood cell count(WBC),and serum CXCL10 in the poor prognosis group were high-er than those in the good prognosis group(P＜0.05).The proportion of lobar pneumonia,pulmonary consolidation,ate-lectasis,and pleural effusion in the poor prognosis group was higher than that in the good prognosis group(P＜0.05).Serum CXCL10(OR=3.823,95％CI:1.526-9.575),lobar pneumonia(OR=3.640,95％CI:1.447-9.154),pulmonary consolidation(OR=4.023,95％CI:1.641-9.865),atelectasis(OR=3.658,95％CI:1.511-8.856),and pleural effusion(OR=3.688,95％CI:1.468-9.264)are risk factors for poor prognosis in patients with severe Mycoplasma pneumoni-ae pneumonia(P＜0.05).The sensitivity,specificity,and area under the curve of serum CXCL10 combined with high-resolution CT imaging features for predicting poor prognosis in patients with severe mycoplasma pneumonia were 0.85,0.62 and 0.867,respectively.Conclusion The combination of serum CXCL10 and high-resolution CT imaging features can be used to evaluate the poor prognosis of patients with severe mycoplasma pneumonia,with good predictive power.
Severe Mycoplasma PneumoniachildrenHigh resolution CTCXC chemokine ligand 10
万方数据
维普
