Objective To understand the drug resistance of tuberculosis in Huadian City,a drug resistance surveil-lance point in Jilin Province,from 2014 to 2023,so as to provide data support for future tuberculosis prevention and control.Methods The tuberculosis patients included in Huadian City in the ten years from 2014 to 2023 were selected,and the drug sensitivity of six drugs was tested by the proportional method drug sensitivity test.The x2 test and logis-tic regression analysis were used for statistical inference,and the drug resistance and related factors of tuberculosis in this area were analyzed.Results Results among the 585 strains of Mycobacterium tuberculosis,279 strains were drug resistant,and the drug resistance rate was 47.7％.The drug resistance rate of newly treated patients was 46.7％,and that of re-treated patients was 55.1％.The single-drug resistance rate was 43.7％,and the single-drug resistance rate of newly treated patients was higher than that of retreatment patients(22.3％vs 10.1％,P=0.020),with statistical significance;there were 85 multidrug-resistant strains,and the multidrug-resistant rate was 30.5％.The multidrug-re-sistant rate of retreatment patients was higher than that of initial treatment patients(24.6％vs 13.2％,P=0.009),and the difference was statistically significant;there were 60 multidrug-resistant strains,and the multidrug-resistant rate was 21.5％.The multidrug-resistant rate of retreatment patients was higher than that of initial treatment patients(18.8％vs 9.1％,P=0.012),and that of male patients was higher than that of female patients(12.3％vs 4.1％,P=0.005),with statistical significance.There were 11 strains with extensive drug resistance,and the rate of extensive drug resistance was 3.9％.The multidrug resistance of Mycobacterium tuberculosis in retreatment cases was 2.064 times higher than that in initial treatment cases(OR=2.064,95％CI:1.045～4.073).The incidence of multidrug resistance of Mycobacterium tuberculosis in men was 3.019 times higher than that in women(OR=3.019,95％CI:1.265～7.206).At the same time,the incidence rate of the area where Huadian City is located will gradually decline before 2020.and the incidence rate will rise by 2023.Conclusion The rates of multidrug resistance and multidrug resistance in retreatment patients and male patients are significantly higher than those in newly treated patients and female patients.It is necessary to further strengthen the prevention and treatment of tuberculosis,especially drug-resistant tuberculosis,especially for retreatment patients and male patients.
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