Distribution,antimicrobial resistance and impact on neonatal outcomes of pathogenic bacteria in placental swab cultures from obstetrics in a hospital during 2020-2022
Objective The aim of this study was to investigate the distribution of pathogenic bacteria in placental swab cultures from obstetrics in a hospital between 2020 and 2022,to analyze their drug resistance,and to explore the impact of these pathogenic bacteria on neonatal outcomes.Methods Clinical data from obstetrical placental swab cul-tures from 2020 to 2022 were collected as study samples.Through standard microbiological methods,placental swab samples were cultured and identified to determine the species of pathogens.At the same time,the identified pathogens were tested for drug susceptibility to evaluate their resistance to different antibiotics.Results the distribution of patho-gens was that Escherichia coli was the main Gram-negative bacteria,ESBLs-producing Escherichia coli was the second;Gram-positive bacteria were mainly Enterococcus faecalis;Fungi are dominated by Candida albicans.The resistance rate of Gram-negative bacteria to penicillin antibiotic ampicillin was the highest(64.59％);Gram-positive bacteria had the highest resistance rate to erythromycin(65.22％);The resistance rate of fungi to the triazole antibiotic itraconazole was the highest(60.00％),while the resistance to the polyene antibiotic amphotericin was not detected.A total of 94 newbo-rns delivered by culture-positive parturients were hospitalized for respiratory symptoms or abnormal blood routine within 24 hours after birth,of which neonatal infection was the main diagnosis in hospitalization(86.17％);Positive culture may have an effect on neonatal hospitalization in the early postnatal period(P＜0.05).When the pathogen is Staphylococcus haemolyticus,the possibility of neonatal hospitalization in the early postnatal period is higher(P＜0.05).Conclusion There is a wide distribution of pathogens in obstetric placental swab cultures,many of which exhibit drug resistance.The presence and resistance of these pathogens are closely related to the outcome of newborns,espe-cially in premature and low birth weight infants.
维普
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