Diagnosis and Treatment of Canine Ovarian Granulosa Cell Tumor
Ovarian granulosa cell tumors in dogs are relatively rare in China.This report presents a case of a dog referred for cough and dyspnea.Laboratory and imaging examinations confirmed an ovarian tumor associated with right middle lobe consolidation,pleural effusion,and peritoneal effusion.The tumor was surgically removed,and further histopathological examination was performed.Hematoxylin-eosin(H.E.)staining revealed loss of ovarian tissue architecture,with tumor cells showing a variety of morphologies,including solid sheets,cords,trabecular,or nest-like arrangements.The cytoplasm was abundant,and the nuclei appeared vacuolated,with rare mitosis.Nucleoli were visible,and chromatin was coarse.Immunohistochemical staining results showed that the specific marker inhibin-α(INH-α)was 5%positive for ovarian granulosa cell tumors,while non-specific markers wilms tumor 1(WT1)and cluster of differentiation 10(CD10)were positive.The dog was diagnosed with an ovarian granulosa cell tumor and staged as malignant.The dog had a good recovery after surgery and was in stable condition at the 3-year follow-up with no recurrence,though continued observation was recommended.This report aims to summarize the diagnostic and treatment processes for ovarian granulosa cell tumors in dogs,providing valuable reference for clinical practice.
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