This study takes a highway high slope as the object,and selects the Duncan-Chang model to establish numerical simulation based on the geological conditions of the region.Through the design of orthogonal experiments,combined with the back analysis of slope displacement monitoring data using BP neural network algorithm,four important slope mechanical parameters are obtained.The results of numerical simulation calculation are close to the measured deformation monitoring data.The research results show that the displacement of the slope can be predicted within a small error range through the comprehensive application of several methods.This conclusion has important reference value for the application of slope protection and early warning technology.