Association between glutamyl transpeptidase and risk of new onset diabetes in middle aged and elderly population
Objective To analyze the association between glutamyl transpeptidase(GGT)and the risk of newly diagnosed diabetes mellitus(DM)in middle aged and elderly population.Methods A retrospective cohort study was conducted,with baseline data sourced from the Beijing sub center population of the"Risk Evaluation of Cancersin Chinese Diabetic Individuals:A Longitudinal Study(REACTION)".A total of 6425 non DM individuals were enrolled in this study.All the participantswere divided into four groups according to GGT levels:G1(GGT<14.6 U/L,n=1601),G2(14.6 U/L≤GGT<19.3 U/L,n=1601),G3(19.3 U/L≤GGT<27.3 U/L,n=1613)and G4(GGT≥27.3 U/L,n=1610)group.They were followed up for 3.2 years.Results During follow-up,556 new DM cases were found,with a cumulative incidence rate of 8.7%.Logistic regression analysis showed that GGT was an independent risk factor for new DM in the non DM population,the risk of new DM in the G3,G4 groups was 1.730 times(95%CI 1.321～2.265,P<0.001)and 1.960 times(95%CI 1.493～2.587,P<0.001)of G1 group,respectively.GGT is also an independent risk factor for new DM in the impaired glucose regulation(IGR),the risk of new DM was 1.530 times higher in the G3 group(95%CI 1.123～2.094,P=0.008),and 1.750 times higher in the G4 group(95%CI 1.271～2.415,P=0.001)than in the G1 group.GGT is not an independent risk factor for new DM in participants with normal glucose tolerance(P>0.05).Conclusions GGT is a risk factor for new onset DM in IGR population.
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