Association of rs3918242 polymorphism in MMP-9 gene with the risk of renal cyst in patients with type 2 diabetes mellitus
Objective To investigate the association between the rs3918242 polymorphism in the matrix metalloproteinase-9(MMP-9)gene and the risk of simplerenal cysts(SRCs)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 483 outpatient with T2DM and inpatient with T2DM admitted to endocrinology department in our hospital were enrolledin this study from June 2020 to December 2023.All the patients were divided into two groups according to the diagnostic criteria for SRCs:T2DM group(n=355)and T2DM with SRCs group(SRCs,n=128).General clinical characteristics and biochemical indicators were compared between the two groups.The correlation between rs3918242 polymorphism and T2DM with SRCs was analyzed by spearman correlation.LASSO regression and stepwise linear regression were employed to identify factors influencing T2DM with SRCs.Multivariate logistic regression analysis was performed to determine the independent risk factors for SRCsin patients with T2DM.Results Serum MMP-9 level was higher in SRCs group than in T2DM group(P<0.05).The frequency of the rs3918242 CT/TT genotypes and T allele was significantly higher in SRCs group than in T2DM group(P<0.05).Spearman correlation analysis demonstrateda positive correlation betweenthers3918242 genotype CT/TT and the presence of SRCs(r=0.344,0.150,P<0.05)and between the T allele frequency and SRCs(r=0.355,P=0.000)in patients with T2DM.Stepwise linear regression identified age,fasting plasma glucose,serum creatinine,albumin,platelet count,estimated glomerular filtration rate(eGFR),calcium levels,MMP-9,and rs3918242 CT/TT genotype as influencing factors for SRCs in T2DM patients.Logistic regression analysis revealed that FPG,albumin,eGFR,Scr,MMP-9,and the rs3918242 CT/TT genotype were independent risk factors for SRCs in patients with T2DM.Conclusions Serum MMP-9 levels areelevatedin T2DM patients with SRCs,and rs3918242 CT/TT genotype in MMP-9 gene areat increased risk for developing SRCs.
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