Research progress on neural circuits of negative emotions induced by chronic visceral pain
Chronic visceral pain and its induced negative emotions reduce the quality of life of sufferers and have large socioeconomic costs.However,the neural circuits and mechanisms associated with it remain unsolved challenges in life sciences.Anterior cingulate cortex and amygdala are the core brain regions responsible for processing chronic pain sensation and emotional components in rodents and humans.Therefore,taking functional gastrointestinal diseases irritable bowel syndrome(IBS)in chronic visceral pain as an example,we focused on these brain regions to highlight the current progress in the neural circuits of negative emotions induced by visceral pain in rodent models of irritable bowel syndrome.In this process,we also discussed important research directions related to this field in the future,providing new clues for revealing the mechanisms of chronic visceral pain and inducing negative emotions.
NETL
NSTL
万方数据
维普
