Pain represents a complex sensory and emotional phenomenon.Acute pain acts as a physiological warning,indicating the necessity to prevent severe injury,while persistent or recurrent pain has the potential to evolve into a chronic condition.The yearly incidence of chronic pain is steadily increasing,impacting over 15%of the global populace and imposing a substantial socioeconomic burden.In recent years,with the advancement of brain imaging technology,extensive research has been conducted to explore the neural circuit mechanisms that modulate the chronicity of acute pain.This article,from the perspective of combining neuroimaging and animal experimental models,elaborated on the potential changes in the sensory perception(thalamus)and emotional processing(limbic system)related brain regions of pain in acute pain chronicity,in order to provide insights for the development of optimal therapeutic strategies for chronic pain.
关键词
急性疼痛慢性化/神经影像学/感觉系统/丘脑-边缘系统
Key words
the chronicity of acute pain/neuroimaging/sensory system/thalamic-limbic system
维普
万方数据