Migraine is a kind of primary headache with high incidence rate and high disability rate.The patho-genesis has not yet been completely elucidated.Recent studies have shown that the microbiota-gut-brain axis may be involved in its pathogenesis.Cholinergic anti-inflammatory pathway(CAP)is an important research field in the microbiota-gut-brain axis.CAP is associated with both headache symptoms and gastrointestinal symptoms of migraine attacks.There have been reports on the correlation between CAP and migraine,as well as the correlation between CAP and gastrointestinal comorbidities with migraine.This review discusses the research progress on the relationship between CAP and migraine,in order to provide new ideas for the study of the pathogenesis of migraine.
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