压电型机械门控离子通道组件 1(piezo-type mechanosensitive ion channel component 1,Piezo1)是哺乳动物体内转导机械刺激信号的主要通道,在调节尿渗透压、控制血压和运动性能、调节上皮细胞增殖与分裂等方面发挥重要作用.机械损伤是炎症诱发因素之一,但机械力诱发炎症的具体机制尚不完全清楚.近年来的研究表明,Piezo1通过介导有关信号通路以及有氧糖酵解等途径调控巨噬细胞参与多种炎症性疾病的过程.本文就Piezo1在该方面的最新研究进展进行综述.
The research progress of mechanical gated ion channel Piezo1 on regulating macrophage-mediated inflammatory responses
Piezo type mechanosensitive ion channel component 1(Piezo1)is the main channel in mammalian body for transduction of mechanical stimulation signals,playing an important role in regulating urinary osmotic pressure,controlling blood pressure and motility,regulating epithelial cell proliferation and division,and so on.Mechanical injury is one of the inducing factors of inflammation,but the specific mechanism of mechanical force induced inflammation is not fully understood.Recent studies have shown that Piezo1 regulates macro-phages in various inflammatory diseases by mediating signaling pathways and aerobic glycolysis.This article provides a review of the latest research progress on Piezo1 in this field.
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