椎间盘源性腰痛(discogenic low back pain,DLBP)是临床上最常见的腰痛类型,约39%的慢性腰痛是由于椎间盘病变引起的.DLBP有着长期、持续、反复的特点,影响病人生活质量和工作效率,对社会也造成了巨大的负担.既往临床上DLBP的治疗方法只能简单缓解疼痛症状并不能治疗椎间盘破裂.近年来富血小板血浆(platelet-rich plasma,PRP)在再生医学领域的应用越来越广泛,体外细胞及动物研究表明其有显著的促椎间盘再生作用.本文以自体PRP在DLBP治疗中的应用进展进行综述,以进一步增强对于DLBP致病机制的认识,并结合自体PRP在临床中的广泛应用,以此为临床DLBP的治疗提供参考.
Research progress of autologous platelet-rich plasma in treatment of discogenic low back pain
Discogenic low back pain(DLBP)is the most common type of low back pain in clinical practice,with approximately 39%of chronic low back pain caused by intervertebral disc diseases.DLBP has the characteristics of long-term,continuous and repeated,which affects the quality of life and work efficiency of the patients,and also causes a huge burden to the society.Previous clinical treatments for DLBP can only simply alleviate pain symptoms and can not treat internal disc disruption(IDD).In recent years,PRP has been more and more widely used in the field of regenerative medicine.In vitro cellular and animal studies have shown that it has a significant effect on promoting intervertebral disc regeneration.In this review,the progress of the application of autologous PRP in the treatment of DLBP was reviewed to further enhance the understanding of the pathogenic mechanism of DLBP and combine the wide application of autologous PRP in clinical practice,so as to provide a reference for the treatment of clinical DLBP.
discogenic low back painautologous platelet-rich plasmagrowth factor
万方数据
维普
