Chronic pain has been a hot area of concern in medical research.The physiological and pathological mechanisms of chronic pain have always been difficult to study,including the transmission,perception and regulatory mechanisms of pain signals.In clinical studies,the occurrence of chronic pain is usually associated with inflammation,tumors,neurodegeneration and other factors.Macrophages,as an important component of the immune system,not only have phagocytic and clearance functions,but also produce a variety of inflammatory factors and cytokines to regulate inflammation and immune responses.Recent studies have shown that macro-phages play an important role in the occurrence and development of various chronic pain,suggesting that they may be one of the effective targets for future pain treatment.This article focuses on the recent advances of macrophages in the field of chronic pain,including the functions and mechanisms of macrophages,as well as the signaling pathways and molecular mechanisms related to macrophages,which provides new ideas and strategies for further research and treatment of chronic pain.
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