巨噬细胞在慢性疼痛中的作用机制和研究进展
Mechanism and research progress of macrophages in chronic pain
田伟 1苏山春 2徐雪琴 2柯昌斌2
作者信息
- 1. 湖北医药学院附属太和医院 麻醉科,十堰 442000
- 2. 湖北医药学院附属太和医院 麻醉疼痛研究所,十堰 442000
- 折叠
摘要
在医学研究中,慢性疼痛一直是备受关注的热点领域.慢性疼痛的生理学和病理学机制一直是研究的难点,其包括疼痛信号的传导、感知和调控机制等.在临床中慢性疼痛的发生通常与炎症、肿瘤、神经损伤等因素有关.巨噬细胞作为免疫系统中的重要成分,不仅起到吞噬清除功能,还能产生多种炎症因子和细胞因子,调节炎症和免疫反应.最近研究表明巨噬细胞在各种慢性疼痛的发生和发展中都起着重要作用,提示其可能是未来治疗疼痛的有效靶点之一.本文将重点讨论巨噬细胞在慢性疼痛领域的最新进展,包括巨噬细胞的功能和作用机制,以及与巨噬细胞相关的信号通路和分子机制,为进一步研究和治疗慢性疼痛提供新的思路和策略.
Abstract
Chronic pain has been a hot area of concern in medical research.The physiological and pathological mechanisms of chronic pain have always been difficult to study,including the transmission,perception and regulatory mechanisms of pain signals.In clinical studies,the occurrence of chronic pain is usually associated with inflammation,tumors,neurodegeneration and other factors.Macrophages,as an important component of the immune system,not only have phagocytic and clearance functions,but also produce a variety of inflammatory factors and cytokines to regulate inflammation and immune responses.Recent studies have shown that macro-phages play an important role in the occurrence and development of various chronic pain,suggesting that they may be one of the effective targets for future pain treatment.This article focuses on the recent advances of macrophages in the field of chronic pain,including the functions and mechanisms of macrophages,as well as the signaling pathways and molecular mechanisms related to macrophages,which provides new ideas and strategies for further research and treatment of chronic pain.
关键词
慢性疼痛/巨噬细胞/炎症/肿瘤Key words
chronic pain/macrophage/inflammation/tumor引用本文复制引用
基金项目
国家自然科学基金(3225018)
2021年度十堰市市级引导性科研项目(21Y30)
出版年
2024
NETL
NSTL
万方数据