The prevalence of chronic pain is on the rise as a result of the progress in contemporary living.Due to the complexity of pain causing factors and the uncertainty of pain pathogenesis,there are still problems of incomplete relief and poor long-term efficacy after treatment,which causes significant mental pressure and loss of control in patients with chronic pain,leading to a decline in their quality of life and social ability.Studies have demonstrated that exercise can effectively alleviate pain by mitigating inflammatory responses,enhancing pain descending inhibitory effect,and ameliorating negative affective states.Hence,exercise,as a low-cost,low-risk,and short-to long-term efficacy combined therapy,holds significant importance in the prevention and treatment of chronic pain.This article reviewed the recent role of exercise therapy in chronic pain and the mechanisms of exercise-induced analgesia,with the aim of providing a basis for exercise rehabilitation in chronic pain patients.