损伤相关分子模式作为内在驱动力参与骨关节炎进程的研究进展

Progress in the study of damage-associated molecular patterns as intrinsic drivers involved in the process of osteoarthritis

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中文摘要：骨关节炎(osteoarthritis,OA)作为中老年人群常见的退行性疾病,其迁延不愈这一特征长期以来困扰着人们,并且造成了医疗消费与日俱增和生活质量下降等一系列问题.目前,OA的治疗方案较多集中于关节内部炎症性疼痛的改善,尚无有效根治手段.相关文献指出巨噬细胞的激活和炎症级联反应的启动与损伤相关分子模式(damage-associated molecular patterns,DAMP)的介导密切相关,DAMP作为驱动剂在关节慢性炎症进程中发挥着至关重要的作用,其不仅存在于关节内部损伤,还可释放入血参与关节外部炎症进程,关节内外的DAMP炎症诱导作用可作为重要驱动力参与OA的进展.本文将从DAMP这一靶点入手,探究DAMP相关的关节慢性炎症正反馈调节机制以及DAMP在OA病人关节外部炎性微环境中的介导作用.

外文摘要：Osteoarthritis(OA),as a common degenerative disease in the middle-aged and elderly population,has long been plagued by its persistent nature,leading to a series of problems such as increasing medical consumption and declining quality of life.At present,the treatment plans for OA mainly focus on improving the inflammatory pain inside the joints,and there is no effective cure.Related literature indicates that the activation of macrophages and the initiation of inflammatory cascade reactions are closely related to the colonization of damage-associated molecular patterns(DAMP).DAMP,as a driving agent,plays a crucial role in the chronic inflammatory process of joints.They not only exist in internal joint injuries,but also can be released into the bloodstream to participate in external joint inflammatory processes.The inflammatory induction of DAMP inside and outside the joint can serve as an important driving force in the progression of OA.This article will start with DAMP and explore the positive feedback regulation mechanism of DAMP-related chronic joint inflammation,as well as the mediating role of DAMP in the inflammatory microenvironment outside the joints of OA patients.

外文关键词：

osteoarthritisdamage associated molecular patterns(DAMP)positive feedback regulationchronic inflammation

作者：

孔舒祎、钱轩韬、王靖、王开强

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作者单位：

上海中医药大学附属市中医医院疼痛科,上海 200071

上海中医药大学临床医学院,上海 200071

山东第一医科大学第二附属医院急诊科,泰安 271000

关键词：

骨关节炎损伤相关分子模式正反馈调节慢性炎症

基金：

上海中医药大学"杏林百人"计划上海中医药大学后备卓越中医人才项目上海市中医医院未来计划上海市中医医院未来计划

项目编号：

上中医人字202023上中医医管字202010WL-HBMS-2022002KWL-HBMS-2022003K

出版年：

2024

DOI：

10.3969/j.issn.1006-9852.2024.05.002

中国疼痛医学杂志

北京大学,中华医学会疼痛学分会

中国疼痛医学杂志

CSTPCD北大核心

影响因子：1.457

ISSN：1006-9852

年,卷(期)：2024.30(5)

参考文献量31