The classical itch signal pathway mediated by histamine and the other non-histamine mediated itch signal pathways are vital in itch generation and sensation.5-hydroxytrptamine(5-HT)or serotonin is a kind of neurotransmitter and a vasoactive amine,causing distinct itch behaviors.Accumulated studies showed that 5-HT and its receptors may play an important role in both acute and chronic itch,while the underlying mechanisms remain not fully clear.Here,we give the brief summary about the function of 5-HT and its receptor family in itch,as well as their related signaling mechanisms,hoping to offer some references for the clinical therapy or drug development of itch-associated diseases.
维普
万方数据