带状疱疹后神经痛研究进展
Recent advancements of postherpetic neuralgia
姬宁宁 1夏明1
作者信息
- 1. 上海交通大学医学院附属第九人民医院疼痛中心,上海 200011
- 折叠
摘要
带状疱疹后神经痛(postherpetic neuralgia,PHN)是由水痘-带状疱疹病毒再激活引起的带状疱疹的最常见并发症.PHN主要由外周传入神经损坏引发的神经系统外周敏化和中枢敏化造成,通过接种疫苗避免带状疱疹仍然是目前预防PHN的最有效手段.在带状疱疹急性期及时的镇痛和抗病毒治疗能有效预防PHN的发生.PHN的治疗主要以药物治疗和微创介入式治疗为主.本文将从PHN的流行病学、发病机制、诊断、预防、预测和治疗角度,详细阐述近年来在PHN领域最新的研究进展.
Abstract
Postherpetic neuralgia(PHN)is the most common complication of herpes zoster,caused by reactivation of the varicella-zoster virus.PHN is primarily characterized by peripheral and central sensitization of the nervous system due to peripheral afferent nerve damage.Vaccination remains the most effective method for preventing PHN by avoiding herpes zoster infection.Timely administration of analgesics and antiviral therapy during the episode of acute herpes zoster can effectively prevent the development of PHN.The treatment of PHN mainly involves medication and minimally invasive interventions.This review will discuss recent advancements in epidemiology,pathogenesis,diagnosis,prevention,prediction and treatment strategies for PHN.
关键词
带状疱疹后神经痛/发病机制/预防/预测/治疗Key words
postherpetic neuralgia/pathogenesis/prevention/prediction/treatment引用本文复制引用
基金项目
上海交通大学医学院附属第九人民医院博士后科研启动基金(202301027)
上海市科学技术委员会医学创新研究项目(23Y11908100)
出版年
2024
NETL
NSTL
万方数据