Mechanism of chronic pain development and maintenance from the perspective of"glia-neuron"interaction
Plasticity changes in neurons are one of the main mechanisms mediating nociceptive sensitization,and the persistence of chronic pain due to nociceptive sensitization seriously affects patients'quality of life.A large number of studies have revealed the close connection and interaction between glial cells and neurons,which are jointly involved in the regulation of chronic pain.Previous studies have mostly focused on the role of activated neurons or glial cells in the regulation of chronic pain,while the information transfer between the two cells has gradually received attention afterwards.Recent studies suggest that glial cells and neurons are involved in the development and maintenance of chronic pain through the action of various neurotransmitters,chemokines,and pro-inflammatory cytokines on the corresponding receptors.In this paper,we take cytokines as an entry point to review the mechanism of glia-neuron interaction in the development and maintenance of chronic pain,hoping to provide a multi-faceted and all-encompassing theoretical reference for cellular and molecular therapeutic strategies for neuroinflammation-mediated chronic pain.
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