Recent progress in research on mechanisms and preventive strategies for remifentanil-induced hyperalgesia
Remifentanil is an opioid medicine,which widely used in clinical practice due to its rapid onset,short half-life,and lack of accumulation with prolonged infusion.Apart from its analgesic effect during surgery,remifentanil can also increase postoperative pain sensitivity,which is known as remifentanil-induced hyperalgesia(RIH).RIH has an significant affect on patients'postoperative recovery and quality of life.The mechanisms of the development of RIH are complex and intricate.This article reviews recent progress in the understanding of the mechanisms and preventive strategies for RIH,aiming to provide theoretical references for future molecular mechanism research and clinical treatment strategies.
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