Clinical observation on wrist-ankle acupuncture in treatment of postherpetic neuralgia and its influence on inflammatory factors
Objective:To explore the clinical effect of wrist-ankle acupuncture in the treatment of postherpetic neural-gia(PHN)and its impact on serum inflammatory factors.Methods:From May 2023 to March 2024,88 patients with PHN at the Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine were divided into an observation group and a control group with the random number table method,44 cases in each group.Patients in the control group were treated with Pregabalin,and patients in the observation group were given wrist-ankle acupuncture treatment for 4 weeks.Visual analogue scale(VAS)scores of the two groups were observed to evaluate the pain levels before treatment,as well as at 7 days,14 days,and 28 days after treatment.The Pittsburgh sleep quality index(PSQI)score,self-rating anxiety scale(SAS)score,self-rating depression scale(SDS)score and serum inflammatory factor level changes before and after treatment were compared.The clinical efficacy of the two groups was evaluated.Simultaneously,the use of emergency analgesics and the occurrence of adverse events during treatment were recorded.Results:With two drop-outs both in the observation group and control group,and 42 cases in each group were included in the analysis.The VAS scores of both groups significantly decreased on days 7,14,and 28 after treatment compared to before treatment(P＜0.05),and the VAS scores of the observation group were significantly lower than those of the control group at all time points after treatment(P＜0.05).There were no significant differences in pre-treatment PSQI scores,SAS scores,SDS scores,and serum IL-6,TNF-α,and CRP levels between the two groups.However,after treatment,PSQI scores,SAS scores,SDS scores,and serum IL-6,TNF-α,and CRP levels in the observation group were significantly lower compared with the control group(P＜0.05).The total effective rate of the observation group was 90.5%,and 83.3%in the control group(P＞0.05).During the treatment,5 cases in the observation group took emergency analgesic drugs,while 11 cases in the control group,with no significant difference(P＞0.05).The adverse reaction rate was 9.52%(4/42)in the observation group,which was significantly lower than 28.57%(12/42)of the control group.Conclusion:Wrist-ankle acupuncture is effective in the treatment of PHN patients,which can effectively reduce the VAS score,improve sleep quality,regulate negative emotions,and inhibit the level of inflammatory factors.The overall clinical efficacy is not inferior to the control group,and the adverse reactions are lower than the control group,so it is worthy of clinical application.
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