Research progress of post-translational modification of ion channels in neuropathic pain
Ion channels are transmembrane protein located on the cell membrane,playing an important role in the occurrence and development of neuropathic pain.Currently,drugs targeted ion channel for the treatment of NP are widely used in clinical practice,but they usually cause a series of adverse reactions.Studies have shown that post-translational modification systems of ion channels can effectively regulate pain by impacting neuronal excitability,synaptic plasticity and membrane transport.Targeting the function of nociceptive ion channels'functions may be a promising avenue for analgesia research.This article aims to review the role of post-translational modified ion channels in the regulation of NP,with a specific focus on ubiquitination,phos-phorylation,palmitoylation and other modifications.The goal is to systematically clarify their key role in pain regulation and provide new targets for the development of novel analgesic drugs for the treatment of chronic pain.
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