Progress on the mechanism of comorbidity between chronic pain and cognitive impairment
Chronic pain refers to pain persisting for more than three months and is often accompanied by cognitive impairment. Approximately 50％ of individuals suffering from chronic pain experience cognitive deficits,which significantly diminishes their quality of life. The mechanisms underlying chronic pain combined with cognitive impairment may encompass several factors:chronic pain may deplete the "cognitive brain resources",resulting in cognitive decline;dysfunction of the locus coeruleus-norepinephrine system induced by chronic pain can lead to abnormalities in cognitive behavior. Additionally,chronic pain can trigger excessive production of pro-inflammatory cytokines within the brain and induce a pro-inflammatory phenotypic transformation in microglia,thereby contributing to cognitive impairment through central nervous system inflammatory responses. Despite numerous studies have addressed the relationship between chronic pain and cognitive impairment,there remains a lack of systematic understanding among researchers and clinicians. Currently,developing pharma-cological targets based on the mechanisms linking chronic pain with cognitive deficits has garnered increasing attention as a focal point for future research and comprehensive summaries of these relevant mechanisms are still lacking. Therefore,this paper aims to synthesize existing knowledge regarding the mechanisms connecting chronic pain with cognitive impairment,provide researchers and clinicians with a systematic framework,lay a theoretical foundation for future therapeutic drug target development aimed at enhancing analgesia and improving cognition.
万方数据
维普
