Objective To analyze the application effect of subject-specific teaching method in clinical teaching of breast cancer.Methods Forty interns from Yongzhou Central Hospital from August 2021 to August 2023 were se-lected as the study objects and divided into control group(n=20)and observation group(n=20)according to random number table method.Conventional teaching teaching method and subdisciplinary teaching method were adopted re-spectively.The excellent rate of teaching method effect evaluation,the pass rate of diagnosis and treatment basic knowledge assessment,the excellent rate of clinical practice ability assessment and the teaching quality score of the two groups were compared.Results The excellent rate of teaching method effect evaluation,the passing rate of basic knowledge assessment diagnosis and treatment,the excellent rate of clinical practice ability assessment and the teach-ing quality score of the observation group were significantly higher than those of the control group,the differences were statistically significant(all P<0.05).Conclusion The application of subject-specific teaching method in clinical teach-ing can improve the clinical teaching effect of interns,enable them to master the basic knowledge of diagnosis and treatment,strengthen the clinical practice ability of interns,and obtain higher teaching quality.