Objective To study the application effect of management concepts with refinement as the core in hospital management.Methods 40 medical staff working in Sheyang County People's Hospital were selected as the research subjects,with routine management implemented from January to December 2022 as the control group,and refined management implemented from January to December 2023 as the study group.The quality of hospital management,work quality of medical staff,overall satisfaction and incidence of adverse events were compared between the two groups.Results The scores of medical safety,management efficiency,medical ethics and style,and innovation and ef-ficiency of the study group were better than those of the control group,the differences were statistically significant(all P<0.05).Ward environmental management,disinfection and isolation management,safety management,drug and item management,and work efficiency scores were better in the study group than those of the control group,the differences were statistically significant(all P<0.05).The total satisfaction of the study group was 100.00%,which was higher than that of the control group(82.50%),the difference was statistically significant(P<0.05).The incidence rate of ad-verse events in the study group was 2.50%,which was lower than that in the control group(20.00%),the difference was statistically significant(P<0.05).Conclusion In hospital management,the application of management concepts with refinement as the core can significantly improve the quality of hospital management,the work quality of medical staff,and the overall satisfaction of medical staff with management content,reduce the incidence of adverse events,and achieve ideal management results.