Information security has received widespread attention in modern society.The information generated in hospital work is diverse,and a considerable portion of it has high value,requiring attention to its security management and protection.This article takes the current situation of information security management in the informatization con-struction of hospital archives as the starting point,and analyzes its security management problems and response strate-gies based on this.It includes emphasizing disaster recovery management,clarifying management rights and responsi-bilities,emphasizing management technology updates,and improving management frameworks.To serve the future construction of hospital archives informatization and provide more support for its comprehensive management.